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Middle East Journal of Cancer، جلد ۶، شماره ۱، صفحات ۴۳-۰
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
ST6Gal1, Cox-2 and HB-EGF mRNA Expression in Breast Cancer Samples from Kashan, Iran |
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| چکیده انگلیسی مقاله |
Background : ST6Gal1, Cox-2 and HB-EGF genes are involved in different tumors and their enhanced expressions often correlate with poor prognosis. In this study we assay the expressions of these genes by reverse transcriptase-PCR in 54 breast cancer samples. Methods : Tissue samples were either formalin-fixed for histopathological examination or frozen for reverse transcriptase-PCR. Image program was used for the densitometry of the image of the gels and the expression of different genes was normalized with beta actin expression. The student's t-test and correlation matrix were used for data analyses. Results : We observed significantly higher expressions of ST6Gal1 (P= 0.040), Cox- 2 (P= 0.001) and HB-EGF (P= 0.009) in the tumor region compared to the margin samples. A significant correlation was found between HB-EGF and Cox-2 expression (P= 0.001). There was a positive correlation between total score, tumor size, histology grade and nuclear grade but there was a reverse correlation between age and tumor size, histology grade and total score. Conclusion : Expressions of ST6Gal1, Cox-2 and HB-EGF in breast tumor samples in this and a number of other studies emphasize their role as important markers in breast cancer . The use of medications to inhibit either their individual expressions or the possible inhibition of all three genes may improve patient survival and prevent metastasis. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
علی اکبر طاهریان | aliakbar taherian
kashan anatomical research center, kashan university of medical sciences, kashan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)
سید مصطفی مصطفوی زاده | seyed mostafa mostafavi zadeh
graduate student, microbiology department, isfahan university of medical sciences, isfahan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
حسین غنی | hossein ghani
department of internal medicine, kashan university of medical sciences, kashan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)
طاهره خامه چیان | tahere khamechian
kashan gametogenesis research center, kashan university of medical sciences, kashan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/index.php/mejc/article/view/183 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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