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Journal of Sciences Islamic Republic of Iran، جلد ۲۹، شماره ۴، صفحات ۳۳۵-۳۴۰
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عنوان انگلیسی Synthesis and Biological Evaluation of 2-Phenyl Benzothiazole Derivatives as Cytotoxic Agents
چکیده انگلیسی مقاله Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, biologically evaluated against breast cancer cell line (T47D) and compared with etoposide as a reference drug.  The anticancer activities were evaluated by MTT colorimetric assay. Among all tested compounds, N-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)acetamide illustrated the most potent cytotoxic activity.
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نویسندگان مقاله L. Firoozpour |
Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

A. Mokhtari |
Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

S. Moghimi |
Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

M. Safavi |
Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran 33535-111, Islamic Republic of Iran

A. Foroumadi |
4Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

نشانی اینترنتی https://jsciences.ut.ac.ir/article_67445_051cc4deceee1ef8649ad8ce2d46c58e.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/513/article-513-858067.pdf
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