این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Basic and Clinical Cancer Research، جلد ۷، شماره ۱، صفحات ۱۶-۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Assessment of Anticancer properties of Artemisia sieberi and its active substance: an in vitro study
چکیده انگلیسی مقاله Background : Artemisinin and its derivatives are well known as anti-malaria drugs and particularly useful for the treatment of infection of Plasmodium falciparum malaria parasites. In recent years, there are many reports of anticancer activities of artemisinins both in vitro and in vivo. This study aimed to investigate the cytotoxicity and anti-angiogenic activity of the ethanolic extract of Artemisia sieberi (EEA) in comparison to its active substance, artemisinin (ART). Methods: The cytotoxic effects of EEA and ART on the HCT-116 colorectal adenocarcinoma cells line were studied by clonogenic assay.The inhibitory effect of test compounds on angiogenesis was evaluated by three-dimensional culture cells model on human umbilical vein endothelial cells (HUVECs) in cytodex-3-microcarriers as in vitro model. Results: The results showed that EEA significantly started inhibition of colony-forming capacity of HCT-116 cells line at concentrations of 1 up to 100µg/ml (P < 0.001). We also found EEA and ART markedly reduced the angiogenic activities on HUVECs culture in a concentration-dependent fashion (P < 0.001, r = 0.997 and P< 0.001, r = 0.998 respectively). Conclusion : It seems that EEA has high cytotoxic effect on HCT-116 cells line and also it is a potent inhibitor of angiogenesis in cultured cells. These results provide the primary findings for further investigations on therapeutic or preventive properties of Artemisia sieberi on cancer.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله زهره عبدالملکی | zohreh abdolmaleki
department of pharmacology, faculty of veterinary medicine university, tehran, iran


حسین علی عرب | hossein ali arab
department of pharmacology, faculty of veterinary medicine university, tehran, iran


سعید امان پور | saeid amanpour
tumor model research center, cancer institute of iran, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کامران منصوری | kamran mansouri
medical biology research center, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

فرخ تیرگری | farrokh tirgari
cancer research center, cancer institute, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/165
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات