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Avicenna Journal of Phytomedicine، جلد ۸، شماره ۴، صفحات ۳۳۰-۳۳۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial
چکیده انگلیسی مقاله Objective: Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations in patients with metabolic syndrome. Materials and Methods: Participants were randomly allocated to one of three groups of 40 subjects receiving either unmodified curcumin or its phospholipid complex or placebo. Lipid profile and plasma CETP were measured at the start and sixweeksafter initiation of the treatment.The normality of data distribution was assessed by Kolmogorov-Smirnov test. Wilcoxon test was used for comparing the data before and after the intervention. The percent changes of CETP and biochemical factors among the three groups were compared using Kruskal-Wallis test. Results: Serum CETP levels were not significantly altered among patients receiving curcumin. Conclusion: Curcumin and its complex had no significant effect on serum CETP concentrations.
کلیدواژه‌های انگلیسی مقاله Metabolic syndrome, HDL-C, CETP, Curcumin, Atherogenesis
نویسندگان مقاله | Ali Javandoost
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Asma Afshari
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Maryam Saberi Karimian
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Amirhosein Sahebkar
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Hamideh Safarian Bana
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Maliheh Moammeri
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Behdokht Fathi Dizaji
Department of Genetic, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Shima Tavalaei
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Gordon A. A. Ferns
Institute for Science and Technology in Medicine, University of Keele, Thornburrow Drive, Stoke-on-Trent, Staffordshire ST4 7QB, UK


| Alireza Pasdar
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Seyed Mohammad Reza Parizadeh
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Majid Ghayour Mobarhan
Biochemistry and Nutrition Research Center, Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
نشانی اینترنتی http://ajp.mums.ac.ir/article_10348.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-684446.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
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