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Iranian Biomedical Journal، جلد ۷، شماره ۱، صفحات ۲۹-۳۳
عنوان فارسی Screening of Lovastatin Production by Filamentous Fungi
چکیده فارسی مقاله In the present study, 110 fungal strains of Persian Type Culture Collection (PTCC) including some selected strains isolated in various screening projects were tested for their potentiality to produce lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. The fungal strains were cultivated in a two-stage submerged fermentation followed by screening by TLC. All positive results were evaluated by confirmatory HPLC. Nine species of four genera were found to be lovastatin producers. Aspergillus terreus was the best lovastatin producing strain with a level of 55 mg lovastatin per liter of screening production medium
کلیدواژه‌های فارسی مقاله Lovastatin، Screening، Fungal strains، Aspergillus terreus
عنوان انگلیسی Screening of Lovastatin Production by Filamentous Fungi
چکیده انگلیسی مقاله In the present study, 110 fungal strains of Persian Type Culture Collection (PTCC) including some selected strains isolated in various screening projects were tested for their potentiality to produce lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. The fungal strains were cultivated in a two-stage submerged fermentation followed by screening by TLC. All positive results were evaluated by confirmatory HPLC. Nine species of four genera were found to be lovastatin producers. Aspergillus terreus was the best lovastatin producing strain with a level of 55 mg lovastatin per liter of screening production medium
کلیدواژه‌های انگلیسی مقاله Lovastatin, Screening, Fungal strains, Aspergillus terreus
نویسندگان مقاله سیامک سمیعی | siamak m samiee


نسرین معظمی | nasrin moazami


سعید حقیقی | saeid haghighi


فرزانه عزیز محسنی | farzaneh aziz mohseni


سعید میردامادی | saeid mirdamadi


محمدرضا بختیاری | mohammad reza bakhtiari


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-284&slc_lang=en&sid=en
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