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Iranian Biomedical Journal، جلد ۱۸، شماره ۲، صفحات ۷۶-۸۱
عنوان فارسی هیدروکورتیزون سبب کاهش بیان مونوسیتی گیرنده Toll-like ۴ در بیماران تحت آنژیوپلاستی می شود
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hydrocortisone Reduces Toll-Like Receptor 4 Expression on Peripheral CD14+ Monocytes in Patients Undergoing Percutanoues Coronary Intervention
چکیده انگلیسی مقاله Bacground: Evidence from several lines of investigations suggests that Toll-like receptor 4 (TLR4) is involved in atherosclerosis as a bridge between innate and acquired immunity. Percutaneous coronary intervention (PCI) can trigger inflammation through activation of human TLR4 (hTLR4) on monocytes. Hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of action. In this study, we aimed at assessing the effects of hydrocortisone on monocyte expression and activity of hTLR4 in patients underwent PCI. Methods: Blood samples were taken from a total of 71 patients with chronic stable angina who were scheduled for a PCI, before the intervention. Thirty patients received 100 mg hydrocortisone prior to the procedure. Control group was composed of 41 patients underwent PCI without receiving hydrocortisone. Blood collection was repeated 2 and 4 h after PCI. The expression of hTLR4 on the surface of CD14+ monocytes and the serum levels of TNF-α and IL-1β were measured using flowcytometry and Sandwich ELISA. Results: Compared with controls, hydrocortisone significantly reduced monocyte expression of hTLR4 in test group (P< 0.01). In addition, it had a significant effect on reduction of serum concentrations of TNF-α and IL-1β in test group in a time-dependent manner (P< 0.01). Conclusion: In this study, hydrocortisone was able to reduce the hTLR4/CD14 positive monocytes and its related pro-inflammatory cytokines, thus it can decrease inflammatory responses following PCI.
کلیدواژه‌های انگلیسی مقاله Toll-like receptor 4, Cytokines, Hydrocortisone
نویسندگان مقاله بهادر باقری | bahador bagheri


بهرام سهرابی | bahram sohrabi


علی اکبر موثق پور | ali akbar movassaghpour


سیمین مشایخی | simin mashayekhi


آفاق گرجانی | afagh garjani


مهریار شکری | mehriar shokri


مسعود پزشکیان | masoud pezeshkian


علیرضا گرجانی | alireza garjani


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-521&slc_lang=en&sid=en
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زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده مقاله کامل
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