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Iranian Biomedical Journal، جلد ۱۹، شماره ۳، صفحات ۱۷۲-۱۷۶
عنوان فارسی Association of Lecithin Cholesterol Acyltransferase rs۵۹۲۳ Polymorphism in Iranian Individuals with Extremely Low High-Density Lipoprotein Cholesterol: Tehran Lipid and Glucose Study
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عنوان انگلیسی Association of Lecithin Cholesterol Acyltransferase rs5923 Polymorphism in Iranian Individuals with Extremely Low High-Density Lipoprotein Cholesterol: Tehran Lipid and Glucose Study
چکیده انگلیسی مقاله Background: The serum concentration of high-density lipoprotein cholesterol (HDL-C) is one of the important heritable risk factors for cardiovascular disease and is a target for therapeutic intervention. In this study, we aimed to evaluate the effects of lecithin cholesterol acyltransferase (LCAT) gene polymorphism rs5923 on LCAT enzyme activity and serum HDL-C concentration. Methods: The study population was selected from consecutive individuals with HDL-C &le 5th percentile (n = 73) and extremely high HDL-C &ge 95th percentile (n = 57) who had participated in the Tehran Lipid and Glucose Study. The rs5923 polymorphism was genotyped using direct sequencing. LCAT activity was measured by fluorometric assay kit, and lipid concentrations were measured using the enzymatic colorimetric method. Results: The genotype frequencies were significantly different between the high HDL-C group (CC 94.7%, CT 5.3%) and the low HDL-C group (CC 83.6%, CT 16.4%) (P = 0.048). The T-allele frequencies in subjects with low and high HDL-C were 0.082 and 0.026, respectively (P = 0.16). The association of the single-nucleotide polymorphism rs5923 with low HDL-C was not statistically significant after adjustment for age, sex, and BMI (odd ratio = 2.65, 95% confidence interval = 0.32-21.5, P = 0.36, regression logistic analysis). Also, the effects of LCAT enzyme activity did not depend on the HDL-C level (P = 0.24). Conclusion: rs5923 polymorphism is not associated with low HDL-C levels in Iranian population
کلیدواژه‌های انگلیسی مقاله Polymorphism, Single nucleotide, Lipoproteins
نویسندگان مقاله محسن ناصری | mohsen naseri


مهدی هدایتی | mehdi hedayati


مریم سادات دانشپور | maryam sadat daneshpour


فاطمه بندریان | fatemeh bandarian


فریدون عزیزی | fereidoun azizi


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-159-1&slc_lang=fa&sid=en
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زبان مقاله منتشر شده fa
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