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Physiology and Pharmacology، جلد ۱۲، شماره ۴، صفحات ۲۵۴-۲۶۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The effect of intrahippocampal injection of diarylpropionitrile, a selective estrogen receptor-beta agonist, on passive avoidance learning |
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| چکیده انگلیسی مقاله |
Introduction: Neurohormones like testosterone and estradiol have an important role in learning and memory. The hippocampus is essentially involved in learning and memory, and is known to be a target for estradiol actions. Estrogen receptors (ERs) are highly expressed in CA1 of rat hippocampus, and mediate the effects of estrogen on learning and memory. Estradiol receptor belong to a family of transcription factors, the nuclear receptor superfamily, and has two subtypes ER and ER. The current research has been conducted to assess the effect of ER selective agonist, diarylpropionitrile (DPN), on passive avoidance of adult male rats, by using passive avoidance task.Methods: Male adult rats were bilaterally cannulated into the CA1 area of hippocampus, and then received vehicle (dimethyl sulfoxide, DMSO) or DPN (0.2, 0.5, 1 micro-g/0.5 micro-l/side), 30 min before training on passive avoidance task.Results: The results showed that pre-training intra-CA1 injections of DPN (0.5, 1 micro-g/0.5 micro-l/side), significantly decreased step-through latencies and increased time spent in dark on passive avoidance learning (P< 0.01).Conclusion: Our data suggest that intra-CA1 administration of DPN could impair learning and memory acquisition on passive avoidance task. |
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| کلیدواژه‌های انگلیسی مقاله |
Estradiol, Estradiol receptor |
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| نویسندگان مقاله |
زینب sharifkhodaei | zeinab sharifkhodaei
department of biology, science and research branch, islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
ناصر نقدی | nasser naghdi
department of physiology and pharmacology, pasteur institute of iran, tehran 13164, iran
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
شهربانو عریان | shahrbanoo oryan
department of biology, tarbiat moalem university, tehran, iran
پریچهر یغمایی | parichehr yaghmaei
department of biology, tarbiat moalem university, tehran, iran
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| نشانی اینترنتی |
http://www.phypha.ir/ppj/browse.php?a_code=A-10-218-2&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Nervous system (others) |
| نوع مقاله منتشر شده |
Original Research |
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