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Physiology and Pharmacology، جلد ۱۵، شماره ۱، صفحات ۱۰۸-۱۱۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of intracerebroventricular injection of olive leaf extract on PTZ-induced seizures in male rats |
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| چکیده انگلیسی مقاله |
Introduction: Olive leaf contains anti-inflammatory and COX-2 inhibitor compounds. Considering the role of the COX enzyme in seizures, this research was performed to assess the effects of this extract in treatment of seizures induced by PTZ. Methods: In this research, male Wistar rats (200±20 g) were injected intra-cerebroventricularly with 1 μl saline or olive leaf extract (125 μg, 250 μg and 500 μg), before the intraperitoneal administration of PTZ (80 mg/kg) for induction of seizure. Then, seizure score and onset times of every stage of seizure were recorded during 20 minutes after PTZ administration. The data was analyzed by one-way analysis of variance (ANOVA) and non parametric tests. Results: Result of this research showed that the injection of 125, 250 and 500 μg of olive leaf extract had no effect on the onset time of seizure stages 1, 2 and 3 compared to the control group (P>0.05). However, they significantly decreased the onset time of seizure stages 4 and 5 compared to the control group (P< 0.05). On the other hand, olive leaf extract decreased onset time of generalized (tonic-clonic) seizures, but had no effect on partial seizures. Different doses of olive leaf extract had no effect on seizure scores. Conclusion: Olive leaf extract has convulsive property and this effect is time and dose dependent. |
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| کلیدواژه‌های انگلیسی مقاله |
Key words, Epilepsy, Olive-leaf extract, PTZ |
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| نویسندگان مقاله |
مرتضی زنده دل | morteza zendehdel
division of physiology, department of basic sciences, faculty of veterinary medicine, univercity of tehran, tehran, iran
کیوان کرامتی | keyvan keramati
department of basic sciences, faculty of veterinary medicine, university of semnan, semnan, iran
سازمان اصلی تایید شده: دانشگاه سمنان (Semnan university)
صدیقه گراوند | sedigheh garavand
master science of physiology
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| نشانی اینترنتی |
http://www.phypha.ir/ppj/browse.php?a_code=A-10-304-4&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Nervous system (others) |
| نوع مقاله منتشر شده |
Original Research |
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