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Avicenna Journal of Phytomedicine، جلد ۸، شماره ۳، صفحات ۲۴۶-۲۵۳
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عنوان انگلیسی In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates
چکیده انگلیسی مقاله Objective: In recent years, there has been an increasing interest in using herbal products to overcome bacterial resistance. The aim of this study was to investigate the effect of lemon verbena aqueous extract, verbascoside and caffeine in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus and Escherichia coli strains. Materials and Methods: The MIC and MBC values of different antibacterial agents against bacterial strains were determined. The effect of co-administration lemon verbena extract, verbascoside, and caffeine and gentamicin was studied in vitro using a checkerboard method and calculating fraction inhibitory concentration index (FICI). Results: Herbal extract, verbascoside and caffeine alone showed no inhibitory effects on any of the bacterial strains (at doses up to 200 mg/ml). Herbal extract, verbascoside and caffeine were able to decrease the MIC of gentamicin against the standard resistant strains and two clinical isolates. Among these combinations, the co-administration of verbascoside and gentamicin was more effective and synergistic activities (FICI< 1)‏ against clinical isolates were observed.‏ Conclusion: The results of the present study revealed that herbal extract, verbascoside and caffeine potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and E. coli.
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نویسندگان مقاله | Bibi Sedigheh Fazly Bazzaz
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, &lrm;Mashhad, Iran


| bahman khameneh
Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, &lrm;&lrm;Mashhad, Iran


| Mohammad Reza Zahedian
ScStudents Research Committee, School of Pharmacy, Mashhad University of Medical Sciences


| Hossein Hosseinzadeh
Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of &lrm;Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_10211.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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