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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۲، شماره ۲، صفحات ۱۳۲-۱۳۵
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چکیده فارسی مقاله
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عنوان انگلیسی T-Cell Prolymphocytic Leukemia: An Experience from a Tertiary Cancer Centre in South India
چکیده انگلیسی مقاله Background: T-cell prolymphocytic leukemia (T-PLL) is a rare lymphoid malignancy with dismal prognosis. Most patients have increased lymphocyte count (>1,00,000/dL) and widespread disease at presentation. Despite high response rate seen with alemtuzumab, the disease relapse is inevitable. Materials and Methods : This was a retrospective observational study done at a tertiary cancer center in South India. All patients diagnosed with T-PLL from August 2010 to July 2015 were studied for the clinical characteristics, pathological findings and treatment outcomes. Results : Seven patients were diagnosed as T-PLL over a period of 5 years. The median age at diagnosis was 51 years. In the present series, 6 patients (86%) had splenomegaly and 3 had hepatomegaly (43%). Generalized lymphadenopathy was seen in 4 (57%) patients at presentation. Skin lesions were seen in 5 (71%) patients, whereas pleural effusion was seen in only one patient (14%). All had elevated total leukocyte count, with more than 1, 00,000/dL in 4 patients. The median survival was 5 months with different chemotherapy (CT) regimens (5 patients treated with CT and 2 received best supportive care). Conclusion: T-PLL is a rare disease with no definite treatment guidelines. At present, the best outcomes are achieved if treatment with alemtuzumab is followed by stem cell transplant, but the disease invariably relapses. Countries where affordability remains a big challenge, the best approach needs to be defined beyond the monoclonal antibodies and transplant.
کلیدواژه‌های انگلیسی مقاله T-cells, Prolymphocytic leukemia, Alemtuzumab
نویسندگان مقاله | Suresh Babu MC
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| Abhishek Anand
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| Kuntegowdanahalli C. Lakshmaiah
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| Govind Babu K
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| Dasappa Lokanatha
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| Linu Abraham Jacob
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| DS Madhumathi
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| Kadabur N Lokesh
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| AH Rudresha
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| LK Rajeev
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India


| Rajesh Patidar


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/814
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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