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International Journal of Pediatrics، جلد ۶، شماره ۵، صفحات ۷۶۰۵-۷۶۱۴
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عنوان انگلیسی The Effect of Mucoadhesive Gel Containing Satureja Hortensis Extract 1% on Severity of Chemotherapy-induced Mucositis Pain in Children: A Randomized Clinical Trial
چکیده انگلیسی مقاله Background: One of the symptoms of mucositis caused by chemotherapy is pain. Mucositis management is initiated by assessment of oral hygiene and management of pain. Many uses have been mentioned for Satureja hortensis in traditional medicine. The study was carried out with the aim of determining the effect of Satureja hortensis extract mucoadhesive gel of 1% on severity of mucositis-induced pain in children under chemotherapy. Materials and Methods This randomized parallel double-blind clinical trial was carried out on 60 children who were affected by mucositis following chemotherapy in 2016. The samples were randomly assigned into two groups of intervention and control. The intervention group applied Satureja hortensis extract gel of 1% and the control group applied the placebo gel twice daily for 5 days after the onset of mucositis along with routine treatment. Oral mucosa was evaluated daily. Also, the Oucher pain tools and a demographic checklist were used. The data was analyzed using SPSS version 13.0 software. Results: The obtained data showed that the two groups had statistical difference in terms of the severity of the pain relief during the time, and pain severity reduced from 3.5±2.1 to 0.0 ± 0.0  in intervention group and 3.1 ± 1.8 to 0.4 ± 1.0 in control group in fifth day (p < 0.001). Conclusion The study showed that the extract 1% of Satureja hortensis is effective in healing mucositis induced pain and can be used as a new treatment method in relieving reducing mucositis pain.
کلیدواژه‌های انگلیسی مقاله Children, Chemotherapy, Mucositis, Pain, Satureja hortensis
نویسندگان مقاله | Mohammad Arshadi bostanabad
Assistant Professor, Department of Nursing, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.


| Amirataollah Hiradfar
Assistant Professor of Pediatric Hematology and Oncology, Department of Pediatric, Tabriz University of Medical Sciences, Tabriz, Iran.


| Asghar Mohammadpoorasl
Assistant Professor, Department of Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


| Yousef Javadzadeh
Professor of Pharmaceutics, Department Pharmaceutics, Tabriz University of Medical Sciences, Tabriz, Iran.


| Bagher Khalvati
MSc in Computer Science, IT Department, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.


| Tahereh Alvandnezhad
MSc in Pediatric Nursing, School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.
نشانی اینترنتی http://ijp.mums.ac.ir/article_9451.html
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