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Middle East Journal of Cancer، جلد ۹، شماره ۲، صفحات ۱۵۱-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran |
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| چکیده انگلیسی مقاله |
Background: Colorectal cancer susceptibility may correlate with the Klotho gene G-395A and C1818T polymorphisms. This study aims to evaluate the relationship between a Klotho single nucleotide polymorphism and IGF-1 with risk of colorectal cancer. Methods: This study enrolled 60 colorectal cancer patients and 60 age-matched healthy persons who referred to Razi Hospital, Rasht, and Northern Iran in September 2013. Patients enrolled under supervision of a gastro-intestinal specialist and according to the ethics right. G-395A and C1818T polymorphisms were genotyped with polymerase chain confronting two pair primer technology. IGF-1 and certain biochemistry analytes were assayed. Statistical analysis was used to compare appropriate relationships. Results: There were different base pair partitions for G395A and C1818T. Odds ratio and 95% confidence interval were used to analyze the correlation of genotypes and haplotypes with colorectal cancer susceptibility. The AA (odds ratio: 1.437, 95% confidence interval: 0.596) and GA (odds ratio: 1.958, 95% confidence interval: 1.133- 3.385) genotypes of the G-395A polymorphisms showed a slight relationship to the risk of colorectal cancer. The A allele had a much higher frequency in the case group (31.2%) compared with the control group (17.6%). There was no significant relationship with the C1818T polymorphism between the case and control groups. Conclusion: The Klotho gene polymorphism did not significantly increase the risk of colorectal cancer. Therefore, these genotypes might not have a correlation with IGF-1. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Mojtaba Fathi
Clinical Biochemistry Department, Zanjan University of Medical Sciences, Zanjan, Iran
| Omid Goodarzvand
Cellular and Molecular Research Center, Department of Biochemistry-Biophysics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
| Monireh Aghjany-Nasab
Gastrointestinal and Liver Diseases Research Center (GLORC), Guilan University of Medical Sciences, Rasht, Iran
| Fariborz Mansour-Ghenaei
Clinical Biochemistry Department, Zanjan University of Medical Sciences, Zanjan, Iran
| Aboalfazl Nazarian
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/index.php/mejc/article/view/713 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/181/article-181-579701.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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