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Medical Laboratory Journal، جلد ۱۲، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی The effect of vigorous aerobic exercise on serum levels of SIRT1 , FGF21 and Fetuin A in women with type Ⅱ diabetes
چکیده انگلیسی مقاله Abstract Background and Objectives :Sirtuin, Fibroblast Growth Factor21 and Fetuin A are proteins which are causing wide spectrum of metabolic disorders such as type Ⅱ diabetes(T2DM). On the other hands, regular physical activity is known as a key element in the prevention and management of T2DM. Thus, this study investigate the effect of vigorous aerobic exercise on serum levels of metabolic parameters, SIRT1, FGF21 and Fetuin A in women with T2DM. Methods:  Total of 28 women with T2DM were randomly selected and divided into two groups(control and exercise). Intervention included 8 weeks of vigorous aerobic exercise(3times per week at 70-80% HR max). The serum levels of SIRT1, FGF21 and Fetuin A were evaluated before the first session and then 48 hours after the last session. The pair sample t test and independent t-test were performed in order to analyze the within and between group  respectively, using SPSS19 software(p ≤ 0.05). Results: Results revealed that 8 weeks of aerobic training led to a significant (p ≤ 0.05) reduction in the weight, body mass index, insulin resistance, LDL, FBS, TG and Fetuin A of women with T2DM and significant increase in SIRT1 and FGF21 between control and exercise group. There was no significant difference between control and exercised groups in terms of HDL and cholesterol levels. Conclusion: It seems that the regular aerobic exercise in women with T2DM can potentially improve the metabolic parameters, SIRT1, FGF21 and Fetuin A. Hence, the regular aerobic exercise can be recommended as a non-pharmacological treatment. Key Words: Type Ⅱ diabetes, SIRT1, FGF21, Fetuin A,  exercise  
کلیدواژه‌های انگلیسی مقاله Type Ⅱ diabetes, SIRT1, FGF21, Fetuin A, exercise
نویسندگان مقاله | Exir Vizvari
Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.


| Parvin Farzanegi
Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran


| Hajar Abbas Zade Sourati
Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran
نشانی اینترنتی http://goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-507&slc_lang=fa&sid=en
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