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Physiology and Pharmacology، جلد ۱۹، شماره ۳، صفحات ۱۴۶-۱۵۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A comprehensive approach to investigate the contradictory effects of metformin therapy in cerebral ischemic injury |
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| چکیده انگلیسی مقاله |
Ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. Metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. Metformin can either protect or damage cells by activating AMP-activated protein kinase (AMPK) and its downstream factors so, it has a dual role in the cerebral ischemia context, but more investigations are needed to define its exact underlying mechanism. Herein, we classify the controversial results of metformin therapy in the experimental models of brain ischemia central and peripheral injection of metformin, chronic and acute treatment, pre- and post-treatment with metformin, tissue-specific role of metformin, dose-specific effect of metformin, age-dependent aspects of metformin therapy. Categorizing different types of cerebral ischemia is important in investigating the dual role of metformin. Due to the variations in metformin therapy, it can be used for chronic treatment, but the patients must be informed about its harmful effects. Although the mechanisms in which AMPK protects/degenerates neurons against ischemic stress situation are still unknown. |
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| کلیدواژه‌های انگلیسی مقاله |
Metformin, AMPK, Glucose, Brain, Ischemia |
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| نویسندگان مقاله |
قربانگل اصحابی | ghorbangol ashabi
physiology research center and department of physiology, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)
فریبا خداقلی | fariba khodagholi
neuroscience research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
شیما زارع شهامتی | shima zare shahamati
neurobiology research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
نگار ghadernezhad | negar ghadernezhad
neuroscience research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
مونا ملکی | mona maleki
neuroscience research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
لیلا خلج | leila khalaj
medical school, alborz university of medical sciences, alborz, iran
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| نشانی اینترنتی |
http://www.phypha.ir/ppj/browse.php?a_code=A-11-881-1&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Neurodegeneretive diseases |
| نوع مقاله منتشر شده |
Review article (by invitation) |
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