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Avicenna Journal of Phytomedicine، جلد ۸، شماره ۲، صفحات ۱۷۹-۱۸۷
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عنوان انگلیسی Doxorubicin-induced renal inflammation in rats: Protective role of Plantago major
چکیده انگلیسی مقاله Objective: The aim of the present study was to evaluate the possible protective effect of Plantago major (P. major) extract against doxorubicin (DXR)-induced renal inflammation in rats. Materials and Methods: 80 male albino rats were randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXR, and Ext1200+DXR. Duration of the study was 35 days and DXR was intravenously injected on the 7th day of the experiment. Tumor necrosis factor-alpha (TNF-α) production and monocyte chemoattractant protein-1 (MCP-1) expression levels were assessed in the left kidney. Serum creatinine concentration and osmolarity were determined on the 1st, 14th, 21st, 28th and 35th days of the experiment. Results: DXR caused a significant increase in renal expression of MCP-1 and TNF-α production compared to control animals. Administration of dexamethasone, vitamin E and P. major extract significantly improved the expression of these inflammatory mediators compared to DXR group. Compared to day 1 in DXR group, serum osmolarity showed a significant increase on days 21, 28 and 35. Also, on these days, serum osmolarity in DXR group was significantly higher than that on the same days in control group. In Vit E+DXR and Ext 1200+DXR groups, there was no significant changes in serum osmolarity among different days of the study. However, in these groups, serum osmolarity on days 21, 28 and 35 showed a significant decrease compared to the same days in DXR group. Conclusion: Present results suggest that hydroethanolic extract of P. major protected renal tissue against DXR–induced renal inflammation.
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نویسندگان مقاله نازنین انتظاری هروی | nazanin entezari heravi
department of physiology, school of medicine, mashhad university of medical sciences mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سارا حسینیان | sara hosseinian
department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

زهره ناجی ابراهیمی یزد | zohreh naji ebrahimi yazd
department of physiology, school of medicine, mashhad university of medical sciences mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمدناصر شافعی | mohammad naser shafei
division of neurocognitive sciences, psychiatry and behavioral sciences research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علیرضا ابراهیم زاده | alireza ebrahimzadeh
department of anatomy and cell biology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سمیرا شهرکی | samira shahraki
department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

زهرا صمدی | zahra samadi
department of physiology, school of medicine, mashhad university of medical sciences mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

فاطمه motejadded | fatemeh motejadded
department of anatomy and cell biology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

فریماه بهشتی | farimah beheshti
department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

رضا محبتی | reza mohebbati
department of physiology, school of medicine, mashhad university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

صغری پرهیزگار | soghra parhizgar
department of physiology, school of medicine, mashhad university of medical sciences mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ابوالفضل خواجوی راد | abolfazl khajavirad
neurogenic inflammation research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_10396.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-574122.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
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