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World Journal of Plastic Surgery، جلد ۷، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی The Effect of Oral Propranolol versus Oral Corticosteroids in Management of Pediatric Hemangiomas
چکیده انگلیسی مقاله BACKGROUND Haemangiomas are the most common benign tumors of infancy. This study evaluated the efficacy of oral propranolol when compared to oral steroids in management of pediatric haemangiomas. METHODS In North India from January 2012 to January 2015, sixty children < 6 years old with superficial haemangiomas were divided into 2 groups; oral propranolol vs. oral prednisolone. All participants were assessed for electrocardiogram, heart rate, blood pressure and sugar and initial therapy was started using 1 mg/kg and in absence of adverse effects, 2 mg/kg was administered after 2 weeks. The Haemangioma Activity Score (HAS) was used for scoring and patients were followed up for 6 months. RESULTS The propranolol group mostly showed early response to the drug and needed the drug for less time compared to corticosteroid group. In propranolol group, 16.5%, 23% and 59% needed the drug to be continued for 8-12, 4-8 and 4 months. In corticosteroid group, the therapy was continued for 8-12, and 4-8 months in 76.8% and 16.5% and in 6.6% was stopped within 4 months. In propranolol group, the response was 70% compared to 40% in other group. The mean HAS decreased significantly in propranolol group when compared to steroid group. Three patients on prednisolone developed Cushingoid features, while 1 patient in propranolol group had mild flue like symptoms. CONCLUSION Two mg/kg of oral propranolol significantly decreased HAS, when compared to oral prednisolone, with good parent satisfaction, minimal adverse effects and no recurrence/relapse of haemangiomas after a follow up period of 6 months.
کلیدواژه‌های انگلیسی مقاله Pediatric haemangiomas, Propranolol, Corticosteroids
نویسندگان مقاله عادل علی | adil ali
jnmch, amu,aligarh


umme ایمن | umme aiman
jnmch, amu,aligarh


محمد اعظم haseen | mohd azam haseen
jnmch, amu,aligarh


محمد altaf میر | mohd altaf mir
jnmch, amu,aligarh


عمران غنی | imran ghani
jnmch, amu,aligarh


ragya bharadwaj | ragya bharadwaj
jnmch, amu,aligarh


محمد یاسین | mohd. yaseen
jnmch, amu,aligarh
نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-170-3&slc_lang=en&sid=en
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