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Medical Laboratory Journal، جلد ۱۱، شماره ۴، صفحات ۳۹-۴۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Letrozole during Pregnancy on Learning and Memory of Offspring Rats |
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| چکیده انگلیسی مقاله |
ABSTRACT Background and Objectives: Hippocampus is the main structure involved in spatial learning and memory consolidation. Formation of spatial memory can be strongly influenced by medications, hormones and different substances. Due to importance of new pharmacotherapy on drug administration in pregnancy, the aim of this study was to investigate the effect of letrozole-therapy during pregnancy on memory and learning in offspring rats. Methods: In this study, 24 pregnant rats were divided into a control and three experimental groups (N=6). The subjects received low dose (0.25 mg/Kg), average dose (0.5 mg/Kg) and high dose (1 mg/Kg) of letrozole orally during 16-19 days of gestation. After maturating, learning and memory of the offspring were assessed by passive avoidance learning apparatus. Data were analyzed by SPSS 20 using one-way analysis of variance and the Tukey's test. P-values less than 0.05 were considered statistically significant. Results: Weights of the offspring who received letrozole decreased significantly compared with the control. There was no significant difference in the step-through latency between the experimental groups. However, the step-through latency and time spent in the dark compartment decreased significantly in the experimental groups compared with control group (P< 0.05). Conclusion: The results of this study show that letrozole can influence learning and memory of offspring rats. Keywords: Letrozole, Gestation, Memory, Learning, Offspring, Rats. |
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| کلیدواژه‌های انگلیسی مقاله |
Letrozole, Gestation, Memory, Learning, Offspring, Rats. |
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| نویسندگان مقاله |
مینو محمودی | minoo mahmoodi
department of biology, islamic azad university, hamadan branch, hamadan, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
مژگان زینی | mozhgan zeini
department of biology, islamic azad university, hamadan branch, hamadan, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-493&slc_lang=fa&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
تحقیقی |
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