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Iranian Journal of Kidney Diseases، جلد ۱، شماره ۱، صفحات ۳۴-۰
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عنوان انگلیسی Low-Dose Doxepin for Treatment of Pruritus in Patients on Hemodialysis
چکیده انگلیسی مقاله Introduction. Pruritus is one of the frequent discomforting complications in patients with end-stage renal disease. We prospectively evaluated the effectiveness of doxepin, an H1-receptor antagonist of histamine, in patients with pruritus resistant to conventional treatment. Materials and Methods. A randomized controlled trial with a crossover design was performed on 24 patients in whom other etiologic factors of pruritus had been ruled out. They were assigned into 2 groups and received either placebo or oral doxepin, 10 mg, twice a day for 1 week. After a 1-week washout period, the 2 groups were treated conversely. Subjective outcome was determined by asking the patients described their pruritus as completely improved, relatively improved, or remained unchanged/worsened. Results. Complete resolution of pruritus was reported in 14 patients (58.3%) with doxepin and 2 (8.3%) with placebo (P Conclusions. We suggest that doxepin, a tricyclic antidepressant with anti-H1 receptor effect, can help improve pruritus resistant to antihistamines in end-stage renal disease patients who undergo hemodialysis. A low dose of doxepin is safe while effective and its main adverse effect, drowsiness, is temporary and can be easily tolerated by the patients.
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نویسندگان مقاله فاطمه پور رضا قلی | fatemeh pour reza gholi


علیرضا نصراللهی | ali reza nasrollahi


احمد فیروزان | ahmad firouzan


انسیه نسلی اصفهانی | ensieh nasli esfahani


فرهت فرخی | farhat farrokhi


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/41
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نوع مقاله منتشر شده ORIGINAL | Dialysis
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