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Iranian Journal of Kidney Diseases، جلد ۲، شماره ۲، صفحات ۷۲-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Interleukin-6 and C-Reactive Protein in Pathogenesis of Diabetic Nephropathy: New Evidence Linking Inflammation, Glycemic Control, and Microalbuminuria |
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| چکیده انگلیسی مقاله |
Introduction. Recent studies have shown that subclinical inflammation is a part of type 2 diabetes mellitus. This study was designed to explore the relationships between low-grade inflammation and renal microangiopathy in patients with type 2 diabetes mellitus. Materials and Methods. Sixty patients with type 2 diabetes mellitus were included in the study and further divided into normoalbuminurics, microalbuminurics, and macroalbuminurics, of 20 patients each. We analyzed serum concentrations of high-sensitivity C-reactive protein (HS-CRP) and interleukin-6 (IL-6) and studied their correlation with proteinuria. The patients and a control group of 20 healthy individuals were followed-up for a period of 6 months and the markers measured again. Results. A positive correlation was found between urinary albumin excretion and levels of HS-CRP (r = 0.781, P Conclusions. Inflammatory markers in early type 2 diabetic nephropathy are elevated and are independently associated with urinary albumin excretion. It is possible to hypothesize on the participation of locally released cytokines in the development of kidney damage. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
nikhil choudhary choudhary | nikhil choudhary choudhary
ravinder s ahlawat | ravinder s ahlawat
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| نشانی اینترنتی |
http://www.ijkd.org/index.php/ijkd/article/view/81 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
ORIGINAL | Kidney Diseases |
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