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JCR 2016
جستجوی مقالات
یکشنبه 27 مهر 1404
Iranian Journal of Kidney Diseases
، جلد ۳، شماره ۱، صفحات ۲۲-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژههای فارسی مقاله
عنوان انگلیسی
Glutathione, Glutathione-Related Enzymes, and Total Antioxidant Capacity in Patients on Maintenance Dialysis
چکیده انگلیسی مقاله
Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Introduction . Oxidative stress due to overproduction of reactive oxygen species and impairment in antioxidant defense mechanisms have been suggested as possible factors contributing to the pathogenesis of atherosclerosis in patients with end-stage renal disease. We compared glutathione levels, glutathione peroxidase and glutathione reductase activities, and total antioxidant capacity between patients on hemodialysis and peritoneal dialysis and healthy individuals. Materials and Methods. Thirty patients receiving regular hemodialysis and 12 on continuous ambulatory peritoneal dialysis were recruited as well as 25 healthy volunteers. Diabetes mellitus, recent febrile or infectious episodes, and hospitalization during the past month were the exclusion criteria. Erythrocyte glutathione level, plasma activities of glutathione peroxidase and glutathione reductase, total antioxidant capacity were determined and compared between the three studied groups. Results . Glutathione levels and glutathione peroxidase activity were markedly lower in the patient groups than in the controls. Conversely, higher activity of glutathione reductase and total antioxidant capacity were noted in the patients than in the controls. There were no significant differences between antioxidant markers of the patients on hemodialysis and peritoneal dialysis. Strong positive correlation were observed between total antioxidant capacity and uric acid in the patients (r = 0.59, P = .045 and r = 0.63, P = .03, respectively). Conclusions. Although total antioxidant capacity of plasma is increased in patient on dialysis, depletion of glutathione as a key antioxidant component and disturbances in its related enzymes show oxidative stress. This condition may increase the risk of developing cardiovascular disease in patients with end-stage renal disease.
کلیدواژههای انگلیسی مقاله
نویسندگان مقاله
پدرام احمدپور | pedram ahmadpoor
ابراهیم افتخار | ebrahim eftekhar
جعفر نوروززاده | jafar nourooz zadeh
حسین ثروت | hossien servat
خدیجه مخدومی | khadijeh makhdoomi
علی غفاری | ali ghafari
نشانی اینترنتی
http://www.ijkd.org/index.php/ijkd/article/view/7
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کد مقاله (doi)
زبان مقاله منتشر شده
en
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نوع مقاله منتشر شده
ORIGINAL | Dialysis
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