این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Kidney Diseases، جلد ۳، شماره ۴، صفحات ۲۲۷-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Different Doses of Oral Folic Acid for Homocysteine-Lowering Therapy in Patients on Hemodialysis: A Randomized Controlled Trial
چکیده انگلیسی مقاله Introduction. We compared the effect of higher and lower doses of folic acid compared to our routine daily dose on plasma homocysteine levels, in our hemodialysis patients. Materials and Methods. Eighty patients on hemodialysis receiving oral folic acid, 10 mg/d, were randomized to receive folic acid at either doses of 5 mg/d (group 1) or 15 mg/d (group 2) for 2 months. Plasma levels of total homocysteine were measured before and after the study period. Results. Hyperhomocysteinemia was seen in 75 patients (93.8%) before, and in 37 patients of group 1 (92.5%) and 39 of group 2 (97.5%) after the study period. In group 1, a nonsignificant decrease occurred in plasma homocysteine level (29.67 ± 12.26 ?mol/L to 27.78 ± 9.94 ?mol/L, P = .30), while in group 2, there was a significant decrease in homocysteine level (32.40 ± 9.76 ?mol/L to 29.58 ± 9.62 ?mol/L, P = .01). Changes in homocysteine level correlated with its baseline level (r = -0.42, P Conclusions. Routine folic acid supplementation of 10 mg/d could not normalize plasma homocysteine levels in most of our patients. Increasing folic acid dose made a statistically significant but clinically trivial decrease in homocysteine levels, and could not normalize homocysteine level in most patients. Patients with a higher baseline homocysteine level achieved a greater reduction, which may be explained by primary noncompliance of some patient. Further investigation of folic acid dosage is suggested.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله شهرزاد عصاره | shahrzad ossareh


حسین شایان مقدم | hossein shayan moghaddam


اشرف سلیمی | ashraf salimi


مژگان عسگری | mojgan asgari


فرهت فرخی | farhat farrokhi


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/208
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده ORIGINAL | Dialysis
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات