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Iranian Journal of Kidney Diseases، جلد ۳، شماره ۴، صفحات ۲۰۳-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Arterial Atherosclerosis in Patients With Chronic Kidney Disease and Its Relationship With Serum and Tissue Endothelin-1 |
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| چکیده انگلیسی مقاله |
Instruction. We investigated the correlation between atherosclerosis and tissue and serum levels of endothelin-1 in patients with chronic kidney disease (CKD). Materials and Methods. Arterial samples were obtained from 35 patients with CKD during arteriovenous fistula placement. Thirty-one patients with cardiovascular disease who underwent coronary artery bypass graft (CABG) were selected as the atherosclerotic group, and a piece of their aorta punched during CABG was obtained. Also, a small piece of the renal artery was dissected during donation in 24 kidney donors (control group). Tissue endothelin-1 level was measured and atherosclerosis grading was determined by pathologic examination. Serum levels of endothelin-1 were also measured in the three groups. Results. The mean tissue endothelin-1 levels were 10.73±7.57 pg/mL, 12.16 ± 3.95 pg/mL, and 0.93 ± 1.06 pg/mL in the patients with CKD, those with CABG, and donors, respectively (P Conclusions. Tissue endothelin-1 concentration is more important than serum endothelin-1 or lipids levels in prediction of atherosclerosis. Thus, blockade of tissue endothelin-1 receptors with its antagonists may prevent atherosclerosis progression. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
حمید نوشاد | hamid noshad
حسن ارگانی | hassan argani
نریمان نظامی | nariman nezami
مرتضی قوجازاده | morteza ghojazadeh
افشار زمردی | afshar zomorrodi
ابوالفضل بهلولی | abolfazl bohlouli
محمدرضا بنیادی | mohammad reza bonyadi
اشرف فخرجو | ashraf fakhrjou
امیر قربانی حق جو | amir ghorbanihaghjo
اباسط قره داغی | abasat gharedaghi
حسن جوادزادگان | hasan javadzadegan
شهرام صدرالدینی | shahram sadreddini
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| نشانی اینترنتی |
http://www.ijkd.org/index.php/ijkd/article/view/107 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
ORIGINAL | Kidney Diseases |
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