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Iranian Journal of Kidney Diseases، جلد ۵، شماره ۶، صفحات ۴۲۰-۰
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عنوان انگلیسی Comparison of Alendronate and Pamidronate on Bone Loss in Kidney Transplant Patients for the First 6 Months of Transplantation
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Calibri","sans-serif"; mso-bidi-font-family:Arial;} Introduction. Osteoporosis develops and progresses in a considerable number of kidney transplant patients. Bisphosphonates, which are used for prevention and treatment of osteoporosis, may accentuate gasterointestinal complications and lead to more nonadherence to treatment. This randomized clinical trial was conducted to compare the effect of pamidronate versus alendronate on early bone mineral density changes in kidney transplant patients. Materials and Methods. Forty patients (27 men and 13 women), aged from 20 to 58 years, with low bone mineral density (T score Results. No significant difference was found in bone density changes of the lumber area between the two groups; however, significantly less reduction in bone mineral density of the femur neck and femur occurred in the pamidronate group. Kidney function and parathyroid hormone levels were similar in the two groups before and after the study. Gastrointestinal side effects were seen in 3 patients of the alendronate group only. Conclusions. Pamidronate was comparable to alendronate in prevention of early bone loss after kidney transplantation.
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نویسندگان مقاله بیتا امیدوار | bita omidvar


علی قربانی | ali ghorbani


حشمت اله شهبازیان | heshmatollah shahbazian


سید سیف اله بلادی موسوی | seyed seifollah beladi mousavi


سید جواد شریعت نبوی | seyed javad shariat nabavi


محمد الستی | mohammad alasti


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/492
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Transplantation
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