Iranian Journal of Kidney Diseases، جلد ۵، شماره ۶، صفحات ۳۹۲-۰
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عنوان انگلیسی Association of Tumor Necrosis Factor-Alpha Gene Polymorphisms With Juvenile Systemic Lupus Erythematosus Nephritis in a Cohort of Egyptian Patients
چکیده انگلیسی مقاله Introduction. The production of tumor necrosis factor (TNF)-alpha has been deeply deregulated in systemic lupus erythematosus. We evaluated the association of -863C>A and -1031T>C polymorphisms of the TNF gene with susceptibility to and clinical manifestations of juvenile systemic lupus erythematosus. Materials and Methods. This study was performed on 70 juvenile patients with systemic lupus erythematosus (mean age, 13.0 ± 4.2 years). Ninety age- and sex-matched children served as a controls. All participants were genotyped for the TNF -863C>A and -1031T>C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism method. Analysis of serum TNF-alpha was done by solid-phase sandwich enzyme immunoassay. Results. The mean serum TNF-alpha was significantly higher in the SLE patients compared to controls (P Conclusions. The -863A allele of the TNF gene can be used as a genetic marker for SLE susceptibility and was associated with high TNF-alpha production, Raynaud phenomenon, and nephritis in juvenile SLE Egyptian patients.
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نویسندگان مقاله tarek m فرید | tarek m farid


abeer محمد نور الدین عبد el بکی حسکویی | abeer mohamed nour eldin abd el baky


ایمان s khalefa | eman s khalefa


احمد a طلعت | ahmed a talaat


امل a محمد | amal a mohamed


tamer a gheita | tamer a gheita


randa f abdel سلام | randa f abdel salam


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/489
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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