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Iranian Journal of Kidney Diseases، جلد ۶، شماره ۴، صفحات ۳۰۰-۰
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عنوان انگلیسی Sirolimus versus Calcineurin Inhibitor-based Immunosuppressive Therapy in Kidney Transplantation: A 4-year Follow-up
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif"; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin;} Introduction. Sirolimus is the one of new immunosuppressants that may be a substitute to traditional drugs such as cyclosporine. We present our investigation on sirolimus-based immunosuppression in kidney transplant recipients as compared with cyclosporine-based immunosuppression. Materials and Methods. We enrolled 100 patients in an open-labeled randomized clinical trial at Shahid Labbafinejad Medical Center. The patients were assigned to one of the immunosuppressive groups to receive either sirolimus or cyclosporine in combination with mycophenolate mofetil and steroids. All kidney transplant recipients were followed up by for serum creatinine and glomerular filtration rate for 4 years. Results. There was no significant differences between the two groups regarding serum creatinine level and GFR until for years posttransplant; however, serum creatinine levels were significantly lower and the GFRs were higher in the sirolimus group after 3 and 4 years. The mean serum creatinine was 1.24 ± 0.28 mg/dL in the sirolimus group and 1.57 ± 0.33 mg/dL in the cyclosporine group at 4 years posttransplant ( P = .02). Also, GFR was 79.8 ± 22.3 mL/min/1.73 m 2 in the sirolimus group and 70.3 ± 23.6 mL/min/1.73 m 2 in the cyclosporine group B ( P = .04). Acute rejection was 1.7-fold higher in the cyclosporine group than in the sirolimus group. Conclusions. Our study demonstrated that sirolimus in the immunosuppressive regimen of kidney transplant recipients had better outcomes regarding graft and patient survival. The effectiveness of sirolimus for kidney allograft recipients should be further assessed to be implemented from the first day after transplantation.
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نویسندگان مقاله محسن نفر | mohsen nafar


بهرنگ علیپور عابدی | behrang alipour abedi


پدرام احمدپور | pedram ahmadpoor


فاطمه پور رضا قلی | fatemeh pour reza gholi


فریبا صمدیان | fariba samadian


شیوا سماوات | shiva samavat


سودابه فرهنگی | soudabeh farhangi


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/847
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Transplantation
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