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Iranian Journal of Kidney Diseases، جلد ۸، شماره ۴، صفحات ۲۶۵-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Role of Renin-Angiotensin-Aldosterone System Gene Polymorphisms andHypertension-induced End-stage RenalDisease in Autosomal Dominant Polycystic Kidney Disease |
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| چکیده انگلیسی مقاله |
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disease of the kidneys and is marked by progressive cyst growth and decline in kidney function, resulting in end-stage renal disease (ESRD). Hypertension is thought to be a significant modifying factor in the progression of renal failure in ADPKD. A number of genetic variations involved in renin-angiotensin-aldosterone system (RAAS) pathway genes have clinical or physiological impacts on pathogenesis of hypertension-induced ESRD in ADPKD. Information on RAAS pathway gene polymorphisms and their association with ESRD and ADPKD, published till March 2013, was collected using MEDLINE search. The present review deals with RAAS gene polymorphisms focused on hypertension-induced ESRD in ADPKD in different populations. The results were inconclusive and limited by heterogeneity in the study designs and the population stratification. In lieu of applying next generation sequencing technologies to study complex diseases, it is also possible to apply the same to unravel the complexity of ESRD in ADPKD. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
gnanasambandan ramanathan | gnanasambandan ramanathan
ramprasad elumalai | ramprasad elumalai
soundararajan periyasamy | soundararajan periyasamy
bhaskar lakkakula | bhaskar lakkakula
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| نشانی اینترنتی |
http://www.ijkd.org/index.php/ijkd/article/view/1433 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
REVIEW | Kidney Diseases |
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