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Iranian Journal of Kidney Diseases، جلد ۹، شماره ۶، صفحات ۴۵۴-۰
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عنوان انگلیسی Effect of N-Acetylcysteine on Inflammation Biomarkers in Pediatric Acute Pyelonephritis: a Randomized Controlled Trial
چکیده انگلیسی مقاله Introduction. This study was designed to investigate the effect of N-acetylcysteine (NAC), as a potent and safe antioxidant, on inflammatory biomarkers of acute pyelonephritis in pediatric patients. Materials and Methods. Children (< 15 years old) admitted with a diagnosis of pyelonephritis were recruited in a randomized placebo-controlled trial. They were randomly allocated to 2 groups and recieved placebo or NAC effervescent tablets with daily dose based on their weight, for 5 days. The children were evaluated for serum procalcitonin level, leukocyte count, C-reactive protein (CRP), serum creatinine, and clinical symptoms on the 1st and the 5th days. Results. Seventy patients, 35 in each group, with a mean age of 5.54 ± 3.10 years completed the study. There was no significant difference between the two groups in the amount of changes in procalcitonin levels after 5 days ( P = .90). Within-group analysis confirmed CRP reduction in both groups ( P < .001); however, between-group analysis did not show significant difference in CRP reductions, either ( P = .65). No significant differences were found between the two groups in the day of resolving pyuria ( P = .46), day of resolving bacteriuria ( P = .81), or reductions in leukocyte count ( P = .64) and neutrophil count ( P = .49). Conclusions. A short period of NAC administration with the recommended doses could not lead to a significant decrease in inflammation biomarkers. Studies on higher doses and longer duration of NAC administration along with evaluation of the long-term effects of the intervention by tools such as renal scntigraphy are suggested.
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نویسندگان مقاله زهرا علامه | zahra allameh


عبدالله کریمی | abdollah karimi


صدیقه رفیعی طباطبایی | seddigheh rafiei tabatabaei


مصطفی شریفیان | mostafa sharifian


جمشید سلام زاده | jamshid salamzadeh


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/2260
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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