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Middle East Journal of Cancer، جلد ۹، شماره ۱، صفحات ۲۷-۰
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| عنوان انگلیسی |
Clinicopathologic Features and Survival of Breast Cancer Subtypes in Northeast Iran |
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| چکیده انگلیسی مقاله |
Background: Breast cancer can be categorized into different histopathological subtypes based on gene expression profiles. The aim of this study was to evaluate the clinicopathological features and overall survival (OS) of various subtypes of breast cancer in order to help diagnosis and guide treatment. Method: The clinicopathologic features of 1095 patients with breast cancer diagnosed over a 10–year period between 2001 and 2011were analyzed. Kaplan–Meier method was used to analyze the disease-free survival (DFS) and overall survival (OS). Calculation of hazard ratio (HR) was conducted by multivariate Cox regression. Results: According to the clinicopathologic characteristics of 1095 cases, 42% were luminal A subtype, 19.2% luminal B, 23% triple negative and 15% Her-2+. The lowest (46.88±12.59 years) and highest (50.54±12.32 years) mean age were in triple negative and Her2+ groups, respectively. There was a significant correlation between histology subtype and age, BMI, lymph node, type of surgery, and stage of disease. Overall survival (OS) and disease free survival (DFS) were significantly shorter in Her-2+ breast cancer patients (P< 0.001). Multivariate analysis showed that age had the highest hazard ratio of 2.481(CI 1.375- 4.477). Conclusion: The results of this study showed the importance of clinicopathological studies of molecular types which helps early diagnosis and identification of best strategy to treat the disease. |
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| نویسندگان مقاله |
سودابه شهیدثالث | soodabeh shahidsales
cancer research center, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
مونا جودی | mona joudi
reza radiotherapy oncology center, mashhad, iran
مرجانه میرصدرایی | marjaneh mirsadraee
molecular medicine group, department of modern sciences and technologies, faculty of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
امیر آوان | amir avan
cancer research center, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
سعیده احمدی سیماب | saeideh ahmadi simab
cancer research center, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
محمدرضا قوام نصیری | mohammad reza ghavamnasiri
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/index.php/mejc/article/view/625 |
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| زبان مقاله منتشر شده |
en |
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| نوع مقاله منتشر شده |
Original Article |
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