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Iranian Endodontic Journal، جلد ۹، شماره ۴، صفحات ۲۷۱-۲۷۶
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عنوان انگلیسی Cytotoxic Effects of Various Mineral Trioxide Aggregate Formulations, Calcium-Enriched Mixture and a New Cement on Human Pulp Stem Cells
چکیده انگلیسی مقاله Introduction: This in vitro study compared the cytotoxic effects of three commercially available MTA formulations naming ProRoot MTA (PMTA), Angelus MTA (AMTA), and Root MTA (RMTA), with calcium-enriched mixture (CEM) cement and a new nanohybrid MTA (NMTA) on human dental pulp stem cells (DPSC). Methods and Materials: Four disc-shaped specimens of each material were prepared. After completion of setting, 2 different (neat and 1/2) elutes of the test materials were made. Then in each cavity of a 96-well plate, 3000 cells were seeded and incubated in a humidified incubator with 5% CO 2 and 95% air at 37 ° C for 24 h. After this period, the culture medium of each well was replaced with 200 μ L of test material elutes. Plain culture medium was used as the negative control and distilled water as the positive control group. Cell viability was assessed using 2, 5-diphenyl-SH-tetrazelium bromide colorimetric assay, aka Mosmann’s tetrazolium toxicity (MTT) assay, at three time intervals (24, 48, and 72 h after mixing). Data were analyzed using the ANOVA and Tukey’s post hoc test ( P =0.05). Results: After 24 h, the viability of cells in neat concentration had no significant differences ( P >0.05) except for the NMTA. However, CEM and AMTA, at 1/2 concentration exerted significant proliferative effects on cells. At 48 and 72-h intervals, significant proliferation of DPSCs was seen in all samples, except for the NMTA which exerted toxic effects on cells. Conclusion: All of the three commercial MTAs and CEM cement showed comparative biocompatibility. However, NMTA had cytotoxic effects on DPSCs at all the time intervals.
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نویسندگان مقاله زهرا جابری انصاری | zahra jaberiansari


صدیقه نادری | seddigheh naderi


فهیمه سادات طباطبایی | fahime sadat tabatabaei


نشانی اینترنتی http://journals.sbmu.ac.ir/iej/article/view/5995
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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