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International Journal of Pediatrics، جلد ۵، شماره ۷، صفحات ۵۲۳۷-۵۲۴۴
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Low Bone Mineral Density and Associated Factors in Patients with Cystic Fibrosis: A Cross-Sectional Study |
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| چکیده انگلیسی مقاله |
Background: Failure to maintain bone mass density is a major complication in patients with cystic fibrosis (CF). This study was conducted to evaluate the prevalence of low bone mineral density (BMD) and also identifying associated risk factors in CF patients. Materials and Methods: Present study conducted on 59 CF patients aged 5-35 years referred to respiratory clinic of Masih Daneshvari Hospital, Tehran-Iran. BMD was measured using dual energy X-ray absorptiometry (DXA) scan. Patients were divided in two groups: cases aged 5-18 years as group A and cases over 18 years as group B. Anthropometric variables, corticosteroid usage, pulmonary function test, serum calcium, phosphate and 25-OH vitamin D were assessed and correlation of them with BMD was investigated. Results: Low BMD (Z score < -2 standard deviation) was found in 72.8% (44) of patients. There was a positive correlation between malnutrition, Forced Expiratory Volume 1 (FEV1) and BMD (r=59 and 0.47, P< 0.01, respectively). Steroid therapy and Pseudomonas aeruginosa colonization correlated significantly inversely with BMD (r = -0.34 and -0.32, P< 0.05). Vitamin D deficiency was found in 36.7% (18) CF patients. No significant correlation was found between 25-OH vitamin D levels and BMD (r = 0.17; P=0. 23). Conclusion: In present study, the prevalence of low BMD was about 72.8% with significant correlation with low weight, BMI (poor nutritional status), FEV1,Pseudomonas aeruginosacolonization and the use of glucocorticoids. |
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| نویسندگان مقاله |
عبدالحمید جعفری ندوشن | abdolhamid jafari nodoushan
assistant professor, department of pediatrics, shahid sadoughi university of medical sciences, yazd, iran.
اعظم گلزار | azam golzar
researcher of children growth disorder research center, shahid sadoughi university of medical sciences, yazd, iran.
مریم حسن زاد | maryam hassanzad
associate professor, pediatric respiratory disease research center,nritld,masih daneshvari hospital,shahid beheshti university of medical sciences,tehran,iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
سید جواد سیدی | seyed javad sayedi
department of pediatrics, neonatal research center, faculty of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
علی اکبر ولایتی | aliakbar velayati
distinguished professor, mycobacteriology research center, national research institute of tuberculosis and lung diseases nritld , shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
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| نشانی اینترنتی |
http://ijp.mums.ac.ir/article_8769.html |
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| زبان مقاله منتشر شده |
en |
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