| چکیده انگلیسی مقاله |
Elevated enzyme activities in plasma may at times be attributed to the presence of macro-enzymes. The macro-enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported. We describe a pediatric patient with persistently elevated serum AST activity, due to macro-enzyme formation between AST and an immunoglobulin. This is to highlight the importance of early diagnosis of macro-AST in an otherwise asymptomatic pediatric patient with isolated AST-elevation and to avoid unnecessary costly testing. |
| نویسندگان مقاله |
wajiha maan | wajiha maan
department of pediatrics, golisano children amp; 039;s hospital, upstate medical university, syracuse, ny, usa.
qurratul ann warsi | qurratul ann warsi
university of california and san francisco, department of epidemiology and biostatistics, san francisco, ca, usa.
آویده راشد | avideh rashed
department of pediatrics, golisano children amp; 039;s hospital, upstate medical university, syracuse, ny, usa.
منوچهر کارجو | manoochehr karjoo
pediatric gastroenterology, hepatology and nutrition, golisano children amp; 039;s hospital, upstate medical university, syracuse, ny, usa.
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