این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۹، صفحات ۹۹۰-۹۹۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Apatinib has anti-tumor effects and induces autophagy in colon cancer cells
چکیده انگلیسی مقاله Objective(s): Apatinib recently has been used to treat patients with gastric cancer, but the function of apatinib in colon cancer remains unclear. This study was conducted to investigate the impacts of apatinib on the biological function and its potential mechanism of colon cancer cells in vitro. Materials and Methods:The effect of apatinib in colon cancer cells were detected by assessing cell viability, migration and invasion capabilities. Apoptosis cells and the cell cycle distribution of colon cancer cells were analyzed by flow cytometry. The potential mechanism was investigated via autophagy related proteins and pathways in vitro. Results: The proliferation, migration and invasion of colon cancer cells were inhibited when they were treated with different concentration of apatinib (20, 40 μM). When HCT116 and SW480 cells were treated with apatinib at the concentration of 20 μM, the apoptosis percentage were 3.7% and 5.8% respectively. As the drug concentration increased to 40μΜ, the the apoptosis percentage increased to 11.9% and 13.5%. Meanwhile, cell cycle was also altered. Furthermore, apatinib inhibited the expression of AKT-mTOR signaling pathway and increased the expression of LC3-Ⅱ. Conclusion: Apatinib can significantly inhibit the malignant phenotype of colon cancer cells, and it was involved in regulation of autophagy.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | ding qianshan
department of gastroenterology, renmin hospital of wuhan university, wuhan, 430060, hubei province, china


| ding qianshan
department of gastroenterology, renmin hospital of wuhan university, wuhan, 430060, hubei province, china


| ding qianshan
department of gastroenterology, renmin hospital of wuhan university, wuhan, 430060, hubei province, china


ونگ zhen | wang zhen
jiangsu hengrui medicine co, ltd, lian yungang, 222047, china


xiang guoan | xiang guoan
department of general surgery, guangdong second provincial general hospital, guangzhou, guangdong, china


yu honggang | yu honggang
department of gastroenterology, renmin hospital of wuhan university, wuhan, 430060, hubei province, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_9263.html
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات