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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۲۹، صفحات ۵۷-۶۴
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عنوان انگلیسی Protective Effects of Quercetin on Spermatogenesis in Streptozotocin-induced Diabetic Rat
چکیده انگلیسی مقاله Background: Quercetin is a strong antioxidant and long-term treatment of STZ-diabetic animals and it has been shown to reduce oxidative stress. Objective: antioxidants have essential effect on spermatogenesis and sperm parameters. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and Quercetin (QR) group that received 15mg/kg (IP) QR, (n=10), and Diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55 mg/kg (IP) STZ plus15mg/kg QR, daily for,4 weeks, respectively however, the control group just received an equal volume of distilled water daily (IP). Diabetes was induced by a single intra peritonea injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for testosterone, TAC, MDA and Ox-LDL levels and testes tissues of Rat in whole groups were removed and sperm was collected from epididymis then prepared for analysis. Results: Sperm population, percentage of sperm viability and motility significantly increased in group that has received 15 mg/kg (IP) Quercetin (p< 0.05) in comparison to control and experimental groups. Conclusion: Since in our study 15 mg/kg (IP) Quercetin have significantly Preventive effect on Sperm percentage of viability and motility by reducing level of Reactive Oxygen Species (ROS) in serum, so it seems that using it can be effective for sperm healthy parameters in Diabetic Rat.
کلیدواژه‌های انگلیسی مقاله Quercetin, Streptozotocin, Spermatogenesis, Rat
نویسندگان مقاله a خاکی | a khaki
no. 1 ettekali la, south shariati street, 5138815941, tabriz, iran, mobile phone 98-9143138-399


m نوری | m nouri
department of biochemistry, tabriz university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

f فتحی آزاد | f fathiazad
department of pharmacognosy tabriz university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

hr احمدی آشتیانی | hr ahmadi ashtiani
clinical biochemistry, tarbiat-e-modarres university, school of medical science, department of clinical biochemistry, tehran, iran and biochemistry amp;amp; nutrition department of zanjan medical university


h رستگار | h rastgar
ministry of health and medical education, food amp;amp; drug laboratory research center, tehran, iran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

sh رضازاده | sh rezazadeh
department of pharmacognosy and pharmaceutics, institute of medicinal plants, acecr, tehran, iran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-176-10&slc_lang=en&sid=fa
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