این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۳، شماره ۳۵، صفحات ۷۱-۷۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Cardioprotective Effect of Garlic Juice on the Isolated Rat Heart in Ischemia- Reperfusion
چکیده انگلیسی مقاله Background: It has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. However, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. Objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in ischemia- reperfusion. Methods: Rat isolated, perfused hearts were subjected to 30 min baseline measurement followed by 40 min normothermic global ischemia and 45 min reperfusion. Garlic juice (0.01 mg/ml) was added to the perfusion solution 20 min before ischemia in the test 1 and 5 min before and 10 min after ischemia in test 2. Different cardiac variables including left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow (CF) were measured. Rate pressure product (RPP) was calculated, and released lactate dehydrogenase (LDH) enzyme in effluent was measured in reperfusion. Results: Garlic juice significantly increased CF before ischemia in both test groups. The released LDH enzyme at the first minute and the recovery of RPP and LVDP on the 45th minute of reperfusion were significantly better in the test group 2 in comparison to the control. Conclusion: The result of the present study shows that garlic juice has a vasodilator activity and protects the isolated ischemic rat heart when it was administrated in reperfusion. It is probably mediated by antioxidant activity of allicin as a principal bioactive compound of garlic juice.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله d شکیبایی | d shackebaei
medical biology research center, kermanshah university of medical sciences, kermanshah, iran tel amp;amp; fax 98-831-4276471, fax 98-831-4276477

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

s قزوینه | s ghazvineh
medical biology research center, kermanshah university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

a گودینی | a godini
medical biology research center, kermanshah university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

a پیله وریان | a pilehvarian
department of biology, school of basic sciences, payame noor university of esfahan

سازمان اصلی تایید شده: دانشگاه پیام نور تهران (Payame noor university)

s رشادت | s reshadat
department of paediatric, school of medicine, kermanshah university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-195-1&slc_lang=fa&sid=fa
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فیزیولوژی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات