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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۴، صفحات ۳۰۷-۳۱۱
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عنوان انگلیسی Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice
چکیده انگلیسی مقاله Objective(s):Bacopa monnieri (BM),a traditional ayurvedic medicine,is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Materials and Methods: Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze. Results: The results showed that BM at the dose of 120 mg/kg significantly (P< 0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity. Conclusion: BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative status.
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نویسندگان مقاله priya verma | priya verma
department of zoology, mahila mahavidyalaya, banaras hindu university, varanasi 221005, india


poonam سینگ | poonam singh
department of zoology, mahila mahavidyalaya, banaras hindu university, varanasi 221005, india


behrose s gandhi | behrose s gandhi
department of zoology, mahila mahavidyalaya, banaras hindu university, varanasi 221005, india
نشانی اینترنتی http://ijbms.mums.ac.ir/article_2590.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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