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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱۲، صفحات ۱۱۸۳-۱۱۸۸
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عنوان انگلیسی Repeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats
چکیده انگلیسی مقاله Objective(s):Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test.Materials and Methods:Orexin-A was microinjected ICV (intracerebroventricular) with an interval of 12 hr for 7 continuous days and its anti-nociceptive responses were measured on days 1, 4 and 7 using the hot-plate test following the first day of administration. Orexin-A was used at a dose of 100 pmol to induce analgesic effects. Results:ICV administration of orexin-A produced an effective anti-nociception on the first day of experiment as measured by hot-plate 5, 15, and 30 min after the injection, in comparison with both baselines (hot-plate test one day before the beginning of orexin-A administration and control, saline-administrated group). However, repeated administration of orexin-A on the following days revealed a significant reduction in this analgesic effect during day 4 to day 7. However, to rule out any associative tolerance resulting from learning related to experimental procedures and/or environmental cues, a single injection of orexin-A was administrated to animals of control group (which were receiving saline during 7 days of experiments) and the analgesic effect was observed. Conclusion:These results, for the first time, indicated the appearance of tolerance to anti-nociceptive effects of orexin-A, following repeated administrations of this agent.
کلیدواژه‌های انگلیسی مقاله Anti-nociception, Hot plate, Orexin-A, Tolerance
نویسندگان مقاله المیرا قاسمی | elmira ghasemi
cellular and molecular research center, sabzevar university of medical sciences, sabzevar, iran


نیما حیدری اورنجقی | nima heidari oranjaghi
department of physiology, zanjan university of medical sciences, zanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

حسن اژدری زرمهری | hassan azhdari zarmehri
neuroscience research center, torbat heydariyeh university of medical sciences, torbat heydariyeh, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تربت حیدریه (Torbat heydariyeh university of medical sciences)

مهدی صادق | mehdi sadegh
department of physiology, faculty of medicine, arak university of medical sciences, arak, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_6270.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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