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Iranian Journal of Public Health، جلد ۴۰، شماره ۲، صفحات ۱۰۲-۱۰۹
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عنوان انگلیسی Beta-Carotene, Vitamin E, MDA, Glutathione Reductase and Arylesterase Activity Levels in Patients with Active Rheumatoid Arthritis
چکیده انگلیسی مقاله Background: Many studies have investigated the possible role of reactive oxygen species in the etiology and patho­gene­sis of Rheumatoid Arthritis (RA). The aim of this study was to investigate the activities of some antioxidants in RA patients. Methods: In this case-control study, 59 RA patients and 60 healthy sex and age-matched controls were selected. Vitamin E and Beta-carotene were determined using HPLC. Erythrocytes glutathione reductase (GR) activity was meas­ured spec­trophotometrically, and malondialdehyde (MDA) was determined by colorimetric method. Aryles­terase activity (AEA) was measured by Phenylacetate. The clinical data were determined by a rheumatologist, medical history and filling the questionnaire by interview. Statistical analyses were carried out using the SPSS software. Results: In patients with RA, serum MDA level was significantly higher and plasma concentration of vitamin E, Beta-carotene and GR activity, were significantly lower than healthy control ( P < 0.001). AEA activity differences between two groups were non-significant. Conclusions: Oxidative stress may play an important role in the inflammation and pathogenesis of RA.
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نویسندگان مقاله n آریاییان | n aryaeian


جلالی | m djalali


f شهرام | f shahram


sh جزایری | sh jazayeri


چمری | m chamari


sa نظری | sa nazari


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/3057
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