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Iranian Journal of Public Health، جلد ۴۱، شماره ۱، صفحات ۵۹-۶۵
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عنوان انگلیسی The -514C/T Polymorphism of Hepatic Lipase Gene among Iranian Patients with Coronary Heart Disease
چکیده انگلیسی مقاله Background: The T allele of the hepatic lipase (HL) C-514T polymorphism was previously found to be associated with lower plasma HL activity. Here, we examined the association between this polymorphism and plasma HDL-cholesterol concentrations in patients with coronary arteries stenosis. Methods: We studied 342 subjects undergoing coronary angiography in two groups of non CAD (n=146) and CAD (n=196). -514C→T polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: After adjustment for age, smoking and body mass index, HDL-cholesterol concentrations were significantly higher in men with the C/T&T/T genotype than those with the C/C genotype(mean 38.6 and 34.7 respectively P=0.01). The frequency of T allele in non CAD was 0.136 and 0.226 in female and male respectively and 0.170 and 0.223 for female and male in CAD subjects. There was no difference in T allele frequency in CAD and none CAD groups in male and female ( P =0.466 and 0.722 respectively). Conclusion: -514C→T of LIPC gene have a positive effect on HDL-C concentration especially in male gender. However, no difference was determined in frequency of T allele between CAD and normal arteries subjects.
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نویسندگان مقاله k قطره سامانی | k ghatreh samani
dept. of biochemistry, school of medicine, shahrekord university of medical sciences, shahrekord, i


محمد نوری موگهی | m noori
drug applied research center and biotechnology research canter, tabriz university of medical scienc

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

m رهبانی نوبر | m rohbani nobar
drug applied research center and biotechnology research canter, tabriz university of medical scienc

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

m هاشم زاده چالشتری | m hashemzadeh chaleshtory
cellular and molecular research center, shahrekord university of medical sciences, shahrekord, iran


e فرخی | e farrokhi
cellular and molecular research center, shahrekord university of medical sciences, shahrekord, iran


m دارابی امین | m darabi amin
drug applied research center and biotechnology research canter, tabriz university of medical scienc

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2634
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