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Journal of Research in Medical Sciences، جلد ۲۲، شماره ۹، صفحات ۰-۰

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عنوان انگلیسی Effects of nanozeolite/starch thermoplastic hydrogels on wound healing
چکیده انگلیسی مقاله Background: Wound healing is a complex biological process. Some injuries lead to chronic nonhealing ulcers, and healing process is a challenge to both the patient and the medical team. We still look forward an appropriate wound dressing. Materials and Methods: In this study, starch?based nanocomposite hydrogel sca?olds reinforced by zeolite nanoparticles (nZ) were prepared for wound dressing. In addition, a herbal drug (chamomile extract) was added into the matrix to accelerate healing process. To estimate the cytocompatibility of hydrogel dressings, fbroblast mouse cells (L929) were cultured on sca?olds. Ten, 3?(4, 5?dimethylthiazol?2?yl)?2, 5?diphenyltetrazolium?bromide assay test and interaction of cells and sca?olds were evaluated. For evaluating healing process, 48 male rats were randomly divided into four groups of four animals each (16 rats at each step). Te ulcers of the frst group were treated with the same size of pure hydrogels. Te second group received a bandage with the same size of hydrogel/extract/4 wt% nZ (hydrogel NZE). Te third group was treated with chamomile extract, and the fourth group was considered as control without taking any medicament. Finally, the dressings were applied on the chronic refractory ulcers of fve patients. Results: After successful surface morphology and cytocompatibility tests, the animal study was carried out. Tere was a signifcant di?erence between starch/extract/4 wt% nZ and other groups on wound size decrement after day 7 ( P < 0.05). At the clinical pilot study step, the refractory ulcers of all fve patients were healed without any hypersensitivity reaction. Conclusion: Starch?based hydrogel/zeolite dressings may be safe and e?ective for chronic refractory ulcers.
کلیدواژه‌های انگلیسی مقاله Chamomile, hydrogel, nanocomposite, ulcer, wound, zeolite

نویسندگان مقاله حسین صالحی | hossein salehi


محمد مهرآسا | mohammad mehrasa


بیژن نصری نصرآبادی | bijan nasri nasrabadi


محسن دوست محمدی | mohsen doostmohammadi


ریحانه سیدابراهیمی | reihaneh seyedebrahimi


نوید داوری | navid davari


محمد rafenia | mohammad rafenia


مهدی ابراهیمیان حسین آبادی | mehdi ebrahimian hosseinabadi


ماریا agheb | maria agheb


منصور سیاوش | mansour siavash



نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10695
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-436727.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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