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Iranian Journal of Public Health، جلد ۴۳، شماره ۱۲، صفحات ۱۶۱۶-۲۶
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عنوان انگلیسی The Efficacy of Leviteracetam versus Carbamazepine for Epilepsy: A Meta-Analysis.
چکیده انگلیسی مقاله Leviteracetam (LEV) is a novel antiepileptic drug with improved tolerance and safety, while carbamazepine (CBZ) represents classical antiepileptic drugs. So far, a systemic comparison of the efficacy and side effects of these two drugs is lacking. A literature review on the comparison of leviteracetam versus carbamazepine for patients with epilepsy was performed up to September 2013 using PubMed, EMBASE, the Cochrane Library and ISI web of science. Finally, 3 randomized controlled trials (RCT) studies met the criteria on comparing the efficacy of leviteracetam versus carbamazepine for patients with epilepsy were included for meta-analysis. Stata 11.0 was used to analyze and summarize the respective data. Three RCTs met the entry criteria. The relative risk (RR) and 95% and the confidence interval (CI) of leviteracetam versus carbamazepine for 6- and 12-month seizure free intervals were 1.0 (0.91-1.10) and 0.97 (0.84-1.13), respectively, for therapy discontinuation due to adverse events (AEs) were 0.62 (0.48-0.80) and 1.00 (0.94-2.05), respectively, and for withdrawal after 6- and 12-month treatment were 0.8 (0.64-0.99) and 0.87 (0.74-1.03), respectively. The RR and 95% CI for occurrence of headache, fatigue, diarrhea, vertigo, nasopharyngitis, depression, weight gain and rash were 0.88 (0.73-1.06), 1.08(0.63-1.83), 1.23 (0.66-2.28), 0.92 (0.49-1.71), 0.85 (0.59-1.22), 2.15 (1.26-3.68), 0.69 (0.45-1.04), 0.39 (0.23-0.68), respectively. The major outcomes such as rate of seizure freedom were similar between leviteracetam and carbamazepine. However, leviteracetam led to depression more frequently than carbamazepine, while carbamazepine caused rash more frequently. However, the limited numbers of available RCTs studies and included patients in this study made our results less convincing and accurate.
کلیدواژه‌های انگلیسی مقاله Carbamazepine,Efficacy,Epilepsy,Leviteracetam,Meta-analysis
نویسندگان مقاله zhaoxia li | zhaoxia li
dept. of pediatrics, the second hospital of shandong university, jinan, china.


zhuanglei امتیاز | zhuanglei gao
dept. of surgery, the second hospital of shandong university, jinan, china.


chengjuan جین | chengjuan jin
dept. of obstetrics and gynecology, qilu hospital of shandong university, jinan, china.


qinghui گیو | qinghui guo
dept. of pediatrics, the second hospital of shandong university, jinan, china.


lihua ونگ | lihua wang
dept. of pediatrics, the second hospital of shandong university, jinan, china.


shandan ونگ | shandan wang
dept. of pediatrics, the second hospital of shandong university, jinan, china.


xue زانگ | xue zhang
dept. of pediatrics, the second hospital of shandong university, jinan, china.


yayun ونگ | yayun wang
dept. of pediatrics, the second hospital of shandong university, jinan, china.
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/3764
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