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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۱، شماره ۱، صفحات ۶۳-۷۷
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Molecular and Cellular Interactions of Allogenic and Autologus Mesenchymal Stem Cells with Innate and Acquired Immunity and Their Role in Regenerative Medicine
چکیده انگلیسی مقاله Mesenchymal stem cells (MSCs), as major stem cells for cell therapy, have been studied from different aspects in preclinical and clinical settings for more than a decade. These cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. Hence, they could be used in regenerative medicine, tissue engineering and immune therapy. MSCs-based therapy have been recently used for treatment of cancer regarding the migratory potential of these cells towards tumor cells which makes them considerable candidates, also for cell therapy in both allogeneic and autologous settings. So, this review attempts to focus on the factors secreted by MSCs such as cytokines, their functional role in mounting and controlling immune responses mediated by different immune cell subpopulations and their significance in regenerative medicine in clinical trials. Although, further studies remain to be done to increase our knowledge of regulating development mechanisms, homeostasis and tissue repair in order to provide new tools to implement the efficacy of cell therapy trials. Although MSCs have been proved safe and effective for cell therapy, there are still challenges to overcome before widely applying MSCs in clinic.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله رقیه حسینی کیا | roghayeh hosseinikia
department of pharmacology, faculty of medicine, yasuj university of medical sciences, yasuj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

محمدرضا نیکبخت | mohammad reza nikbakht
college of veterinary medicine, razi university, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

علی اصغر مقدم | ali asghar moghaddam
medical biology research center, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

احمد تاجه میری | ahmad tajehmiri
department of health education and nutrition, faculty of public health, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

محبوبه حسینی کیا | mahboobe hosseinikia
medical biology research center, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

فرهاد عوبری | farhad oubari
iranian blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

مهین نیکوگفتار ظریف | mahin nikougoftar zarif
department of health education and nutrition, faculty of public health, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

یحیی پاسدار | yahya pasdar
medical biology research center, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

کامران منصوری | kamran mansouri


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/554
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/78/article-78-430398.pdf
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زبان مقاله منتشر شده en
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