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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۱، شماره ۱، صفحات ۲۴-۲۹
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عنوان انگلیسی The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD following Hematopoietic Stem Cell Transplantation
چکیده انگلیسی مقاله Background: The study attempts to assess the relationship between chimerism analysis using polymerase chain reaction of short tandem repeat (STR) and the incidence of chronic graft versus host disease (GvHD) as well as survival. Methods: The retrospective cohort included all patients who received allo-HSCT between 2005 to 2013. Data collected by day +100 were reviewed in terms of the incidence of chronic GvHD and survival . Chimerism was evaluated for whole blood, T-cell and PMN cells on days 15, 30 and 60, respectively using polymerase chain reaction of short tandem repeat (STR). Results: Forty (69%) patients developed chronic GvHD, 11 (19%) relapsed and 22 (39.7%) died during the study. There was a significant relationship between chronic GvHD and chimerism analysis including whole blood on day 60 (P=0.001), PMN on day 60 (p= 0.05) and T-cell on days 15 (p=0.028), 30(p=0.01) and 60 (p=0.004) . Patients with chronic GvHD showed a long-term survival as compared with those without chronic GvHD (P=0.0013). Conclusion: Conducting continuous analysis of chimerism provides an opportunity to initiate immediate measures to prevent complications.
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نویسندگان مقاله سید اسدالله موسوی | seyed asadollah mousavi
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

مینا جوادی مقدم | mina javadimoghadam
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اردشیر قوام زاده | ardeshir ghavamzadeh
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کامران علی مقدم | kamran alimoghaddam
center for academic and health policy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آزاده سیاری فرد | azadeh sayarifard
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید حمیداله غفاری | seyed hamidollah ghaffari
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهرام چهاردولی | bahram chahardouli
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی باسی | ali basi


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/558
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/78/article-78-430394.pdf
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زبان مقاله منتشر شده en
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