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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۱، شماره ۲، صفحات ۱۵۸-۱۶۳
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عنوان انگلیسی Evaluation of E-Cadherin Expression in Gastric Cancer and Its Correlation with Clinicopathologic Parameters
چکیده انگلیسی مقاله Background: Gastric cancer is one of the most common cancers in the world . There are many genomic and molecular factors that cause gastric cancer to occur. Also, many markers that associate with tumor invasiveness have been known. E-Cadherin is a calcium- mediated cell adhesion molecule. In some studies, abnormal expression of E-Cadherin has been seen in gastric carcinoma. However, in the studies done there has been some conflicting information about abnormal expression of this marker in a variety of gastric carcinoma and also about the expression of this marker and its correlation with various clinicopathologic factors of tumor. Subjects and Methods: A case control study was performed on total or partial gastrectomy tissue samples obtained from 70 patients with gastric cancer and adjacent non-neoplastic tissues. The immunohistochemistry was used to assess E-Cadherin expression. The correlation between abnormal E-Cadherin expression and tumor histopathology was evaluated in all patients. Results: Among 70 patients who were analyzed, 48.6% showed abnormal E-Cadherin expression . A significant correlation was seen between abnormal E-Cadherin expression and tumor stage, grade, lymph node metastasis, tumor phenotype, tumor type, depth of invasion and age. Conclusion: Abnormal E-Cadherin expression is a common phenomenon in gastric cancer. Because there was a strong correlation between abnormal E-Cadherin expression and tumor stage, tumor grade, depth of invasion and regional lymph node involvement, this marker may be used as a predictive factor for tumor invasiveness in gastric cancer.
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نویسندگان مقاله ژیلا ترابی زاده | zhila torabizade
md, assistant professor, department of pathology, school of medicine, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

آناهیتا نصرتی | anahita nosrati
md, resident, department of pathology, school of medicine, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

سیده ندا سجادی ساروی | seyedeh neda sajadi saravi
md, associate professor, department of biostatistics, school of public health, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

جمشید یزدانی چراتی | jamshid yazdani charati
md, associate professor, department of internal medicine, school of medicine, gastrointestinal cancer research center, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

قاسم جان بابایی | ghasem janbabai


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/501
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زبان مقاله منتشر شده en
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