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Iranian Journal of Public Health، جلد ۴۴، شماره ۱۰، صفحات ۱۳۳۹-۱۳۴۷
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عنوان انگلیسی Effect of Genistein and L-Carnitine and Their Combination on Gene Expression of Hepatocyte HMG-COA Reductase and LDL Receptor in Experimental Nephrotic Syndrome
چکیده انگلیسی مقاله Background: Nephrotic syndrome is a disorder that leads to hyperlipidemia. L-carnitine and genistein can effect on lipid metabolism and the syndrome. In the present study, we have delved into the separate and the twin-effects of L-carnitine and genistein on the gene expressions of HMG-COA reductase and LDL receptor in experimental nephrotic syndrome. Methods: In this controlled experimental study, 50 male Sprague–Dawley rats were randomly divided into five groups: NC (normal-control), PC (patient-control), LC (L-carnitine), G (genistein), LCG (L-carnitine-genistein). Adriamycin was used for inducing nephrotic syndrome and the spot urine samples and urine protein-to-creatinine ratio were measured. Hepatocytic RNA was extracted and real-time PCR was used for HMG-COA Reductase and LDL receptor gene Expression measurement. Results: The final weight of the patients groups were lower than the NC group ( P =0.001), and weight gain of the NC group was higher than the other groups ( P < 0.001). The proteinuria and urine protein-to-creatinine ratio showed significant differences between PC group and LC, G and LCG groups at week 7 ( P < 0.001). The expression of HMG-COA Reductase mRNA down regulated in LC, G and LCG groups in comparison with PC group ( P < 0.001). ΔCT of LDLr mRNA showed significant differences between the PC group and the other patient groups ( P < 0.001). Conclusion: This study shows a significant decreasing ( P < 0.001) and non-significant increasing trend in HMG-COA Reductase and LDLr gene expression, respectively, and synergistic effect of L-carnitine and genistein on these genes in experimental nephrotic syndrome.
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نویسندگان مقاله عباس یوسفی نژاد | abbas yousefinejad


فریدون سیاسی | fereydoon siassi


عباس | abbas mirshafiey


محمد رضا اشراقیان | mohammad reza eshraghian


فریبا کوهدانی | fariba koohdani


محمد حسن جوانبخت | mohammad hassan javanbakht


رضا seda ghat | reza seda ghat


آتنا رمضانی | atena ramezani


مهناز زارعی | mahnaz zarei


محمود جلالی | mahmoud djalali


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/4997
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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