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Iranian Journal of Public Health، جلد ۴۵، شماره ۳، صفحات ۳۲۲-۳۲۸
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عنوان انگلیسی Antifungal Susceptibility Analysis of Clinical Isolates of Candida parapsilosis in Iran
چکیده انگلیسی مقاله Background: Candida parapsilosis is an emergent agent of invasive fungal infections. This yeast is one of the five most widespread yeasts concerned in invasive candidiasis. C. parapsilosis stands out as the second most common yeast species isolated from patients with bloodstream infections especially in neonates with catheter. Recently several reports suggested that its reduced susceptibility to azoles and polyene might become a cause for clinical concern, although C. parapsilosis is not believed to be intensely prone to the development of antifungal resistance. Methods: In the present report, One hundred and twenty clinical isolates of C. parapsilosis complex were identified and differentiated by using PCR-RFLP analysis. The isolates were then analyzed to determine their susceptibility profile to fluconazole (FLU), itraconazole (ITC) and amphotericin B. The minimum inhibitory concentration (MIC) results were analyzed according to the standard CLSI guide. Results: All of isolates were identified as C. parapsilosis . No C. metapsilosis and C. orthopsilosis strains were found. Evaluation of the antifungal susceptibility profile showed that only three (2.5%) C. parapsilosis were resistant to fluconazole, three (2.5%) C. parapsilosis were resistant to itraconazole and two (1.7%) C. parapsilosis were amphotericin B resistant. Conclusion: Profiles in clinical isolates of C. parapsilosis can provide important information for the control of antifungal resistance as well as distribution and susceptibility profiles in populations.
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نویسندگان مقاله انسیه لطفعلی | ensieh lotfali


پریوش کردبچه | parivash kordbacheh


حسین میرهندی | hossein mirhendi


زینی | farideh zaini


علی قجری | ali ghajari


رسول محمدی | rasoul mohammadi


فاطمه نوربخش | fatemeh noorbakhsh


مریم mo azeni | maryam mo azeni


علی اکبر فلاحی | aliakbar fallahi


ساسان رضایی | sassan rezaie


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/6264
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زبان مقاله منتشر شده en
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