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Iranian Journal of Public Health، جلد ۴۵، شماره ۴، صفحات ۴۸۵-۴۹۳
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عنوان انگلیسی Characterization of Staphylococcus aureus Biofilm Formation in Urinary Tract Infection
چکیده انگلیسی مقاله Background: The aim of this study was to investigate the antibiotic susceptibility pattern as well as the phenotypic and genotypic biofilm formation ability of Staphylococcus aureus isolates from patients with urinary tract infection (UTI). Methods: A total of 39 isolates of S. aureus were collected from patients with UTI. The antibiotic susceptibility patterns of the isolates were determined by the Kirby-Bauer disk-diffusion. We used the Modified Congo red agar (MCRA) and Microtiter plate methods to assess the ability of biofilm formation. All isolates were examined for determination of biofilm related genes, icaA , fnbA , clfA and bap using PCR method. Results: Linezolid, quinupristin/dalfopristin and chloramphenicol were the most effective agents against S. aureus isolates. Overall, 69.2% of S. aureus isolates were biofilm producers. Resistance to four antibiotics such as nitrofurantoin (71.4% vs. 28.6%, P =0.001), tetracycline (57.7% vs. 42.3%, P =0.028), erythromycin and ciprofloxacin (56% vs. 44%, P =0.017) was higher among biofilm producers than non-biofilm producers. The icaA , fnbA and clfA genes were present in all S. aureus isolates. However, bap gene was not detected in any of the isolates. Conclusion: Our findings reinforce the role of biofilm formation in resistance to antimicrobial agents. Trimethoprim-sulfamethoxazole and doxycycline may be used as an effective treatment for UTI caused by biofilm producers S. aureus . Our results suggest that biofilm formation is not dependent to just icaA , fnbA , clfA and bap genes harbor in S. aureus strains.
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نویسندگان مقاله مسعود یوسفی | masoud yousefi


محمد رضا پورمند | mohammad reza pourmand


فاطمه فلاح | fatemeh fallah


علی هاشمی | ali hashemi


راحیل مشهدی | rahil mashhadi


علی نظری عالم | ali nazari alam


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/6579
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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