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Journal of Research in Medical Sciences، جلد ۲۲، شماره ۳، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effects of probiotic supplement on hemoglobin in chronic renal failure patients under hemodialysis: A randomized clinical trial
چکیده انگلیسی مقاله Background: Chronic inflammation is one of the causes of anemia in chronic renal failure patients under hemodialysis. Probiotics probably establish a balance between pro- and anti-inflammatory cytokines. Te study was conducted to determine the effects of probiotic supplementation on hemoglobin (Hb) in hemodialysis patients. Materials and Methods: A parallel clinical trial was conducted in which patients were randomly allocated into two groups. Te intervention group ( n = 18) was given a 500 mg probiotic supplement (a capsule) every day whereas the control group ( n = 18) received placebo (a capsule), both for 3 months. Hb levels and C-reactive protein (CRP) levels were measured for three periods. Te data were analyzed in SPSS-16 using statistical tests including the t -test and repeated-measures ANOVA. Results: In the probiotic supplementation group, the mean Hb was 9.22 ± 1.04 mg/dl before the intervention and reached 10.85 ± 1.177 mg/dl afterward, while in the placebo group, the mean Hb level was 9.38 ± 0.97 mg/dl before the intervention and reached 10.03 ± 1.97 mg/dl afterward ( P > 0.05). During the study, the placebo caused to increase of Hb temporary, but in longer term, the effect of probiotic was more manifested. Hb levels increased in both groups although the change was not statistically significant ( P > 0.05). Te findings showed no significant differences between the two groups in either the pre- or post-intervention CRP levels ( P = 0.239). Conclusions: Probiotic supplementation decreased Hb fluctuations in hemodialysis patients but did not result in a significant increase in Hb levels. Similar studies are therefore recommended to be conducted with a prolonged duration of the study or an increased probiotic dose with larger sample size to complete the results of the present study. Key words: Chronic renal failure, hemodialysis, hemoglobin, probiotic
کلیدواژه‌های انگلیسی مقاله Chronic renal failure, hemodialysis, hemoglobin, probiotic
نویسندگان مقاله زهرا شریعتی | zahra shariaty
department of nephrologhy, emam hosein hospital, sharoud university of medical sciences, sharoud, iran.


غلام رضا محمودی shan | gholam reza mahmoodi shan
assistant professor, vice chancellor of nursing research center and health research center member, golestan university of medical sciences, gorgan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

مهران | mehran farajollahi
department of nephrology, shahroud university of medical sciences, shahroud,


منیره عامریان | monireh amerian
department of nephrology, 5 azar hospital, golestan university of medical sciences, gorgan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

ناصر بهنام پور | naser behnam pour
assistant professor, health research center, golestan university of medical sciences, gorgan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10660
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-421747.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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