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Iranian Endodontic Journal، جلد ۱۲، شماره ۳، صفحات ۳۵۴-۳۵۹
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عنوان انگلیسی In Vitro Cytotoxicity of GuttaFlow Bioseal, GuttaFlow 2, AH-Plus and MTA Fillapex
چکیده انگلیسی مقاله Introduction: The aim of the present in vitro study was to evaluate the cytotoxicity of different sealers including GuttaFlow Bioseal, GuttaFlow 2, AH-Plus and MTA Fillapex on L929 murine fibroblasts. Methods and Materials: Samples of GuttaFlow Bioseal, GuttaFlow 2, AH-Plus and MTA Fillapex were fabricated in Teflon disks of 5 mm diameter and 3 mm thickness. L929 fibroblasts were exposed to the extracts of these materials for 3, 24, 72 and 168 h at 37 ° C with 5% CO 2 . Cell viability was evaluated by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Apoptosis was evaluated by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The data were analysed by ANOVA. Results: GuttaFlow Bioseal was nontoxic at all experimental time points ( P >0.05), whereas MTA Fillapex and AH-Plus were toxic ( P < 0.001). At 7 days, there were more viable cells in the GuttaFlow 2 group than in the control group, and MTA Fillapex was more cytotoxic than AH-Plus. There were more apoptotic cells in the MTA Fillapex and AH-Plus groups than in the other groups at 3 h ( P < 0.001). Conclusion: GuttaFlow sealers are less cytotoxic than MTA Fillapex and AH-Plus. At all experimental time points, there was no significant difference in the cell viability between the GuttaFlow Bioseal group and the control group.
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نویسندگان مقاله gokhan saygili | gokhan saygili


suna saygili | suna saygili


ابراهیم tuglu | ibrahim tuglu


اسماعیل davut capar | ismail davut capar


نشانی اینترنتی http://journals.sbmu.ac.ir/iej/article/view/15415
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/109/article-109-413967.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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