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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲، شماره ۲، صفحات ۴۲-۴۵
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عنوان انگلیسی Early Hepatic Complication in First Year after Bone Marrow Transplantation in Major Beta Thalassemic Patients
چکیده انگلیسی مقاله Introduction: Bone marrow transplantation is a good therapeutic modality for beta thalassemia. Liver complications are one of the major causes of morbidity and mortality following BMT. Determination of the factors of liver injury leads to earlier diagnosis after BMT and improves prognosis. Method: We studied 113 major Beta thalassemic patients who have been transplanted from 1990- 2000 in bone marrow transplantation center of Shariati Hospital. 62 were male and 51 were female. 27 pa‌tients were class one, 56 were class two and 30 were class three. The median age of each class were 6.5, 6.3 and 8.7. Conditioning regimen consisted of busulfan (3.5-4mg/Kg) and cyclophophamide (40-50mg/Kg).For GVHD prophylaxis we gave cyclosporine ± metothoroxate. Grade of liver fibrosis de‌fined by biopsy in all patients before BMT. All patients and their donors tested for HBSAg, HBSAb, HCVAb, CMVAb with RIA method. We assessed causes of liver dysfunction before and after trans‌plantation and effect of high ferritin level on liver function. Results: Hepatic dysfunction in first year after transplantation was seen in 86 (76%) patients. Causes of liver dysfunction were consisted of 53.1% GVHD, 15.93% cyclosporine hepatotoxicity, 7.07% condi‌tioning regimen hepatotoxicity and VOD. In all three classes hepatic GVHD, cyclosporine toxicity, death and normal liver function post BMT had significant relation with hepatic dysfunction before BMT (P=0.001). In patients with ferritin level more than 1000, there were significant hepatotoxicity with conditioning regimen (P=0.001). 17 (15.04%) of patients have been died. Discussion: According to our study hepatic GVHD (%53.1) is the most common cause of hepatic dys‌function in all three classes.
کلیدواژه‌های انگلیسی مقاله BMT,Thalassemia,Hepatic complications
نویسندگان مقاله مجید ایروانی | m iravani
assistant professor of hematology- oncology, hematology- oncology and bmt research center shariati hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m arshy | m arshy
general practitioner, hematology- oncology and bmt research center shariati hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m توتونچی | m toutounchi
general practitioner, hematology- oncology and bmt research center, shariati hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

l nedaeifard | l nedaeifard
pediatrician, hematology- oncology and bmt research center, shariati hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a قوام زاده | a ghavamzadeh
professor of hematology- oncology hematology- oncology and bmt research center, shariati hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/191
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